Brain Hypoxia

The brain edema - the pathological condition, the described accumulation of a liquid in a fabric of a hypertensions of brain and intracranial from the standpoint clinic showed by a syndrome.

There are 4 basic types of edema of brain:

- cellulotoxic
- vasogenic
- interstitiel
- Osmotique.

They differ by etiology, the development time, location and the methods of discussion and the preventive treatment

The edema of Cellulotoxic appears because of to increase by glia, neurocyte and endotheliocyte and begins in some minutes after the damages of a brain, for example hypoxia. Following the decrease in a Na of activity of metabolism +, K + -to the phases that a cell membrane is broken. Sodium collects in a cell, and on a slope of pressure osmotique in a cell water begin acting. The edema of Cellulotoxic basically is localized in the gray substance of a brain.

The edema of Vasogenic is the version more frequented of a hypostasis of a brain. It develops because of the increase of permeability of capillaire ones. By a wall of capillaire ones in the space extracellulaire there are fibers, and after the - waters. the edema of vasogenic basically is localized in the white substance of a brain.

The edema interstitiel develops to a hydrocephaly because of the difficulty of pressure of exit ventricule of interior of an increases of brain. Under the action of this pressure there is a strengthened filtering of water and the molecular low substances in the fabric of a brain surrounds by the ventricules.

The ischemia of a brain takes once more to cellulotoxic, and then - to the edema of vasogenic. Thus, the picture of pathophysiological is so normal that some people suggest using the term "an edema ischedmique". In the first minutes of an ischemia develops the edema of cellulotoxic principally mentioning astrocytes that around are localized of capillaire ones. If the blood provision quickly is restored, these changes arrive to be behind. Otherwise because of the growth of cells of astrocytes and endothelial the glimmer of capillaire ones then is reduced, even after the restoration of blood of provision of blood cannot act in the capillaire ones. It worsens an ischemia and necroses it.

In a permeability of edema of vasogenic of phase of a wall of capillaire student. It is showed, that it arrives the cause of increases of pinocytosis and following the offence of dense contacts between the cells of endothelium. After the restoration of a permeability of blood fluting of barrier of blood brain increases even more. Just like to the others form edema of vasogenic.

Simultaneously with cellulotoxic and necroses it edema of vasogenic develops. Glia and neurocyte in a bigger degree are the subject of necroses in comparison of endothelium. In the process of their destruction in the intercellular substance of a brain a substances osmotiquement active that takes to a bigger production equals water of the capillaire ones collect.

Does the hypostasis ischedmique attain a maximum on 2-4-? the day after an assault of heart and the decreases of here the end of the second week. More in the field of necroses inflammatory reaction, including the phagocytosis develops. In several days or in several weeks resolutions necrotic of weight, and the hypostasis disappears. Believe, that the hypostasis can cause an ischemia and by that to increase a zone of an assault of heart.